Angels vs. Guardians prediction, odds, time: 2026 MLB picks for Monday, May 11 from proven model
Angels vs Guardians Preview
Jose Ramirez and the AL Central-leading Cleveland Guardians open a nine-game homestand by hosting Mike Trout and the Los Angeles Angels on Monday. The Guardians sit at 21-21 and continue to lead the Central despite dropping two of three to their division rival Twins over the weekend. The Angels, at 16-25, have won three of five, including a 6-1 victory over the Blue Jays on Sunday. Left-hander Joey Cantillo (2-1, 3.43 ERA) will take the mound for Cleveland, while Alek Manoah is expected to follow the opener for Los Angeles in his second appearance of the season. First pitch from Progressive Field in Cleveland is set for 6:10 p.m. ET.
Angels vs Guardians odds and picks
Cleveland is a -175 favorite on the money line (risk $175 to win $100), with the over/under set at 7.5. The latest betting information also covers various prop and matchup markets for this matchup, including the run line.
The SportsLine Projection Model simulates every MLB game 10,000 times and is coming off a 5-0 week on top-rated MLB picks. It previously excelled at home run prop bets in 2025, delivering substantial profit. The model has now locked in its Angels vs Guardians selections, and you can see its picks by visiting SportsLine.
Angels vs Guardians betting lines
– Money line: Guardians -175, Angels +147
– Over/Under: 7.5 runs
– Run line: Guardians -1.5 (+130)
Top Angels vs Guardians predictions
After 10,000 simulations, the model recommends the Over 7.5 combined runs. The Under had been a trend for Angels games, hitting in seven straight before the total split 2-2 in the last four. Guardians games have gone over in three of four, with the three recent games finishing 9-13 runs. The model notes the Over is favored in Cantillo’s starts for Cleveland, and it projects 8.9 combined runs for this game. The Angels, who average 3.4 runs at home, post a 5.0 runs-per-game figure on the road, the sixth-highest in MLB. The model also projects 1.5 total bases or more for Jo Adell, Zach Neto and Trout, while Ramirez, Angel Martinez, Kyle Manzardo and Chase DeLauter are expected to reach 1.5 total bases for Cleveland. You can view the full set of Angels vs Guardians predictions and picks at SportsLine.
