Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 9

Game Info

Date: Saturday, May 9, 2026
Time: 7:15 p.m. ET
Venue: Petco Park — San Diego, California
Coverage: FOX

Moneyline: SD (-146) | STL (+124)
Spread: SD -1.5 (+136) | STL +1.5 (-164)
Total: 8 — Over (-105) | Under (-115)

Starting Pitchers
Randy Vasquez (Padres) – 3-1, 3.20 ERA
Dustin May (Cardinals) – 3-3, 5.15 ERA

This matchup is set, with Randy Vasquez taking the mound for the Padres and Dustin May for the Cardinals. Vasquez’s team is 5-2-0 against the spread this season in his starts. They are 3-1 this season when he starts and they are the moneyline favorite. The Cardinals have gone 4-3-0 ATS in May’s seven starts with a set spread. They are 3-3 in May’s six starts this season when they were the moneyline underdog.

Prediction: Padres win (57.9%)

Looking at the moneyline for Padres-Cardinals, San Diego is the favorite at -146, and St. Louis is +124 playing on the road. The Padres are hosting the Cardinals and are favored by 1.5 runs (+136 to cover) on the runline. St. Louis is -164 to cover. A combined run total of 8 has been set for Padres-Cardinals on May 9, with the over at -105 and the under at -115.

The Padres have been chosen as favorites in 22 games this year and have walked away with the win 12 times (54.5%) in those games. This year San Diego has won nine of 14 games when listed as at least -146 on the moneyline. The Padres’ games have gone over the total in 16 of their 38 opportunities. The Padres are 21-17-0 against the spread in their 38 games with a line set by sportsbooks this season.