Dodgers vs Astros Prediction, Picks & Odds for Today’s MLB Game

Game Info:
Location: Daikin Park, Houston, TX
Date: Monday, May 4, 2026
First pitch: 8:10 p.m. ET
TV: SportsNet LA, SCHN

Dodgers starting pitcher: Yoshinobu Yamamoto (2-2, 2.87 ERA)
Astros starting pitcher: Steven Okert (0-0, 4.20 ERA)

Dodgers vs Astros odds
Moneyline: Dodgers -186 | Astros +178
Over/Under: Over 9 | Under 9

The Los Angeles Dodgers and Houston Astros start a three-game series tonight when the teams meet at Daikin Park. The Astros are dealing with a rash of injuries, which is why my Dodgers vs. Astros predictions have L.A. winning easily. Here are my free MLB picks for Monday, May 4. Who will win Dodgers vs Astros today: Dodgers -1.5 (-125)

The Houston Astros have four starting pitchers injured at the moment, which is why Steven Okert is set to start in what will be a bullpen game. Unfortunately for the Astros, their bullpen has posted a 6.69 ERA and 5.70 FIP over the past two weeks. It’s silly to expect them to suddenly turn things around against a loaded Los Angeles Dodgers lineup sporting the third-lowest strikeout rate over the past two weeks. Houston’s offense is dealing with injuries as well, and will find it hard to score enough against Yoshinobu Yamamoto. The Dodgers will cover the spread here. COVERS INTEL: Over the last two weeks, Houston’s bullpen has allowed a 52.6% pull rate and a 25% line drive rate, both among the worst marks in baseball. Enjoying Covers content? Add us as a preferred source on your Google account

Dodgers vs Astros Over/Under pick: Over 9 (-115)

The Astros should not get blanked tonight, especially with hitters like Yordan Alvarez in the lineup. Yamamoto has been somewhat fortunate, given his xERA of 3.98 is more than a run higher than his 2.87 ERA. Opponents are having real success vs. his four-seam fastball, slugging .548 vs. a .257 mark a season ago. He’s also having less success with his splitter, a pitch he utilizes 30% of the time. Shohei Ohtani is due to break out, and likely will against this Houston bullpen. His .053 ISO and .214 BABIP over the past week are starkly at odds with his .348 xwOBA.

Trend:
The Astros have hit the team total Over in 16 of their last 24 games at home (+6.95 Units / 24% ROI). Find more MLB betting trends for Dodgers vs. Astros.