Brewers vs Cardinals Prediction, Picks & Odds for Today’s MLB Game

Game Info:
Location Busch Stadium, St. Louis, MO
Date Tuesday, May 5, 2026
First pitch 7:45 p.m. ET
TV Brewers.TV, Cardinals.TV

Brewers starting pitcher: Brandon Sproat (0-2, 6.75 ERA)
Cardinals starting pitcher: Andre Pallante (3-2, 3.73 ERA)

Moneyline: Brewers -110 | Cardinals -110
Run line: Brewers -1.5 (+160) | Cardinals +1.5 (-190)
Over/Under: Over 8 (+100) | Under 8 (-120)

Trend:
The Milwaukee Brewers have hit the Game Total Under in 15 of their last 25 away games (+5.25 Units / 19% ROI). Find more MLB betting trends for Brewers vs. Cardinals.

AI MODEL:
MIL 40% STL 60%

Cordell’s prediction: The Brewers rebound and level their series with the Cardinals. 

The Milwaukee Brewers dropped the series opener to the St. Louis Cardinals 6-3 at Busch Stadium. My Brewers vs. Cardinals predictions expect the road team to flip the script, taking on a pitcher they’ve had plenty of success against. Let’s dive deeper into my daily MLB picks for Tuesday, May 5.

Brandon Sproat’s xFIP and SIERA sit about two full runs below his ERA, suggesting his surface numbers don’t tell the whole story of how he’s pitched. He’s also improved as the season has progressed, logging more than 16 innings in each of his last three starts while allowing four, four, and six hits, respectively. If he can keep the ball in the yard, the Brewers will be in good shape. Andre Pallante has shown concerning numbers against left-handed hitters (47.2% hard-hit rate, 13.2% barrel rate), and Milwaukee features plenty of lefty pop in their lineup. COVERS INTEL: Pallante has allowed 17 runs over his last four starts against Milwaukee.

Brewers vs Cardinals Over/Under pick: Under 8.0 (-120)

Sproat has been better lately at limiting baserunners. Untimely homers have inflated totals at times, which is less of a concern in 50-degree weather with winds blowing in. If Sproat can navigate the early innings, Milwaukee can lean on a bullpen that ranks fifth in xFIP and is tied for third in homers allowed per nine innings. Colder weather and Pallante’s high ground-ball rate (50%) should help the Cardinals keep the long ball in check, making it harder to score in bulk and pushing this game toward the Under.