Dodgers vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 6

MLB action on Wednesday features the Los Angeles Dodgers taking on the Houston Astros. Here’s what you need to know before checking today’s MLB odds and spreads on FanDuel Sportsbook.

Game Info:
Los Angeles Dodgers (22-14) vs. Houston Astros (15-22)
Date: Wednesday, May 6, 2026
Time: 2:10 p.m. ET
Venue: Daikin Park — Houston, Texas
Coverage: SCHN and SportsNet LA

Moneyline: Dodgers -220 | Astros +184
Runline: Dodgers -1.5 (-132) | Astros +1.5 (+110)
Total: 8.5 — Over -106 | Under -114

Starting Pitchers:
Tyler Glasnow (Dodgers) 3-0, 2.56 ERA
Lance McCullers (Astros) 2-2, 6.32 ERA

The Dodgers will send Glasnow to the mound looking for win No. 4 on the season, while the Astros will counter with McCullers. Glasnow starts have the Dodgers at 3-3-0 against the spread this season, and his team is 5-1 this year when he starts as the moneyline favorite. The Astros have gone 3-3-0 ATS across McCullers’ six starts with a set spread. Houston has been the moneyline underdog in four of McCullers’ starts this season, going 2-2 in those games.

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (58.2%)

The Dodgers are the moneyline favorite at -220, with Houston, at +184, as the home underdog. The Dodgers are 1.5-run road favorites on the runline against the Astros, with Dodgers -132 to cover and Astros +110 to do so.

The May 6 matchup carries an over/under of 8.5 runs, with the over at -106 and the under at -114.
Bet on Los Angeles Dodgers vs. Houston Astros on FanDuel today!

Team context
The Dodgers have 22 wins in 36 games when listed as the favorites this season. They are 10-5 when favored by -220 or more. Dodgers games have gone over the total in 16 of 36 opportunities, and they are 17-19-0 against the spread in their 36 games with a sportsbook line this season.

Houston’s stance
The Astros are 9-11 as moneyline underdogs (winning 45% of those games). Houston has not yet played a game this season with moneyline odds of +184 or longer. They have appeared in 37 games with an over/under set, going over 24 times (24-12-1). The Astros are 15-22-0 ATS this season (covering 40.5%).

Dodgers Player Leaders
Andy Pages leads Los Angeles with a .500 slugging percentage, fueled by 13 extra-base hits. He is batting .326 with an on-base percentage of .368. Among qualified hitters in the majors, his batting average ranks 10th, his on-base percentage ranks 44th, and he is 31st in slugging. Pages is aiming for his eighth straight game with a hit in this matchup. In his last 10 games he is hitting .308 with three doubles, two walks and six RBIs.