Phillies vs Red Sox Prediction, Picks & Odds for Today’s MLB Game

Location: Fenway Park, Boston, MA
Date: Tue, May 12, 2026

Moneyline: Phillies -133 | Red Sox +127
Run Line: Phillies -1.5 (+122) | Red Sox +1.5 (-127)
Over/Under: Over 8.5 (+108) | Under 8.5 (-113)

Matchup Preview
The Philadelphia Phillies and Boston Red Sox can swap stories of early-season gloom when they meet at Fenway Park tonight—but only one of these teams has managed to halt the spiral. While Boston drifts further from the .500 mark, Philadelphia is looking dangerous at last, and my Phillies vs. Red Sox predictions tilt toward the visitors in this marquee matchup. Get the lowdown on this Tuesday, May 12, with my free MLB picks.

Prediction: Phillies (-138)

What a difference a few weeks can make. Just when the obituaries were being written, the Philadelphia Phillies have climbed off the mat to win 10 of their last 13, and I like Bryce Harper and Co. in this spot against the Boston Red Sox. It also helps that the Phillies are handing the ball to Zack Wheeler tonight. He’s posted a 3.18 ERA so far this year, and Philadelphia has won all three of his starts. After an eyebrow-raising sweep of the Tigers, the Red Sox came back to earth with a weekend series loss, and they’re just 7-12 at Fenway this season.

Over/Under Pick: Over 8.5 (+101)

With the Phillies heating up at the plate, I’m taking the Over tonight. It’s 7-3 in the visitors’ past 10 outings, and they plated 22 runs in the weekend series against the Rockies, including four homers from Kyle Schwarber, with Alec Bohm and Harper also contributing. Philadelphia has also finished with 9+ hits in five of its last six games, so expect solid production, with Boston likely using an opener before turning things over to Brayan Bello. The Red Sox offense is the bigger hurdle here, but the potential return of Willson Contreras would give the lineup a boost.

Phillies vs Red Sox Trend
The Red Sox have lost nine of their last 12 home games.